Papaya LeafOral Enzyme Therapy combines various proteases (protein dissolving enzymes) in order to prevent disease, assist the body to fight various cancers, and lessen the negative effects of chemotherapy and radiation. The proteolytic enzymes papain and chymopapain are found naturally in the papaya leaf.

Memorial Sloan Cancer Center Site explains possible Mechanism of Action:

“PEs (proteolytic enzymes) are thought to exert immunomodulatory effects by causing increased release of reactive oxygen species by polymorphonuclear leukocytes or by production of tumor necrosis factor-alpha and interleukins IL-6 and IL-1B that cause cytotoxic effects.

The antiangiogenic effects that papain exhibits in VEGF-activated human endothelial cells is concentration-dependent and likely due to interference with AKT, MEK1/2 and SAPK/JNK phosphorylation. Bromelain has been shown to lower the tumorigenic/metastatic capacities of sarcoma L-1 cells. It also inhibited glioma cell migration and invasion by affecting expression of integrins, necessary for cellular migration and invasion. In B16 murine melanoma models, PEs inhibited metastasis by reducing expression of CD44 and CD54 molecules.”

http://www.mskcc.org/cancer-care/herb/proteolytic-enzymes

One example of a clinical trial that documented the lessened effect of radiation on cancer patients who took oral enzyme therapy is below:

Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects.

Authors
Dale PS1, Tamhankar CP, George D, Daftary GV.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S29-34.

http://www.ncbi.nlm.nih.gov/m/pubmed/11561869/

“CONCLUSIONS: In patients with locally advanced cancer of the uterine cervix, oral enzyme therapy was found to be effective in significantly reducing radiation therapy-related side effects such as genitourinary symptoms, subcutaneous changes and reactions of the vaginal mucosa.”

In another clinical study, oral enzyme therapy was an effective complementary treatment for patients undergoing chemotherapy and radiation:

“…CONCLUSION: Complementary treatment of colorectal cancer patients with OE improves their quality of life by reducing both the signs and symptoms of the disease and the adverse reactions associated with adjuvant antineoplastic therapies. This epidemiological retrolective cohort analysis provides evidence that patients may also benefit by a prolongation of survival time. OE were generally well tolerated.”

PMID 11561874 [PubMed – indexed for MEDLINE]

Influence of a complementary treatment with oral enzymes on patients with colorectal cancers–an epidemiological retrolective cohort study.

Authors
Popiela T1, Kulig J, Hanisch J, Bock PR.
Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S55-63.

http://www.ncbi.nlm.nih.gov/m/pubmed/11561874/?i=3&from=/11561869/related

Set of Minerals in Papaya Leaf May Explain Medicinal Value

Scientists show a strong mineral set in the papaya leaf. The manganese specifically helps the body absorb enzymes. The powerful protease enzymes papain and chymopapain in the papaya leaf (which are considered cancer and inflammation fighters) may find a path to absorption through the manganese.

“…It has now been found that certain proteolytic enzymes are activated in the presence of ions of calcium, magnesium, manganese, cobalt or combinations thereof… Preferred for use as single activators are calcium and magnesium.”

-Activated enzyme compositions
US 3019171 A. 1957

http://www.google.com/patents/US3019171

International Journal of Scientific & Engineering Research, Volume 4, Issue 6, June-2013 1012

ISSN 2229-5518

Estimation of Minerals in Carica papaya L. Leaf found in Northern India by using ICP-OES Technique

Dinesh Kumar Sharma, Prof. B. Tiwari, Rabindra Kr. Singh, Sandeep Sahu, S. C. Mathur, R. M. Singh & G. N. Singh

The study on CP leaves done herewith has shown very rich minerals composition in green, yellow and brown leaves, which were collected from the plain as well as hill area of Northern India and CP leaves, can be seen as a potential source of useful drug, food & dietary supplement. The brown leaf can be used as anti-anaemic agent. It possesses immune-stimulants with anti-oxidant property. In the recent case study report, CP leaves extract controls dengue infection, has opens new gateway and raised eyebrows of many scientists. On the other hand, the presence of important anti-oxidants & vitamins may suppress various free radicals species induced during the viral infection. Particularly, the mineral composition may balance the mineral deficiency promoted by the virus and strengthen the immune cells against the dengue virus. The usefulness of these nine minerals obtained, like Ca, Mg, Mn, Na, K, Fe, Zn, Cu and Cr, which are found in rich quantity in CP leaves. The minerals are the elements that originate in the Earth and cannot be made by living organisms. Plants obtain minerals from the soil, and most of the minerals in our diets come directly from plants or indirectly from animal sources.

…Manganese (Mn) plays an important role in a number of physiologic processes as a constituent of multiple enzymes and an activator of other enzymes. A number of manganese- activated enzymes play important roles in the metabolism of carbohydrates, amino acids and cholesterol17.

…Manganese activates several enzyme systems and supports the utilization of vitamin C, E, choline, and other B-vitamins.

In Conclusion,
Therefore, papaya leaves due to its potent therapeutic properties can be formulated in herbal formulations as a medicine/dietary supplement and may be marketed as a nutraceutical product and as well as drug in curing the several diseases like Dengue fever, malaria etc.

http://www.ijser.org/paper/Estimation-of-Minerals-in-Carica-papaya-L-Leaf-found-in-Northern-India-by-using-ICP-OES-Technique.html

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